Epitome Hardcore

The Perfect Pre

• Increase Energy
• Improve Strength
• Enhance Muscle Volumization
• Boost Endurance
• Heighten Mental Focus

Description

What is the perfect example of a pre-workout supplement? You’re looking at it. The best pre workout will check all the boxes: Energy, Pump, Focus, and Performance. Epitome exists to make you the perfect representation of your physical aspirations – whether they are to have more muscle, less body fat, or more strength. Using a well-rounded profile of the best science has to offer, Epitome was built to smash plateaus and create perfection.

Don’t let your efforts go unnoticed. Become better by capitalizing on every biological pathway that contributes to better performance and body composition. Be the Epitome.

Ingredients

Vitamin B6

One of the essential B vitamins

• Supports nutrient metabolism and the effective harnessing of energy from food.
• Vitamin B6 also aids endurance by participating in the formation of hemoglobin and improve oxygen consumption

Vitamin B3

An essential B complex vitamin with broad effects

• Also known as niacin
• Helps improve mental acuity, reduce fatigue, and support endothelial health for better blood flow.

Beta-Alanine

Intense exercise creates lactic acid, a metabolic byproduct, which causes the infamous “muscle burn.” Beta-alanine helps make exercise easier without reducing its great effects by helping to buffer – reduce the acidity – of lactic acid

• The result is enhanced endurance and performance in the gym.
• This has been exemplified by improved spring performance and body composition development.

L-Citrulline

L-Citrulline is a nitric oxide-generating amino acid that has far superior bioavailability and efficacy than L-arginine

• L-Citrulline increases vascularity and improves work capacity – an extremely important factor for maximizing gains.
• L-Citrulline is not destroyed in the liver, like arginine, and therefore is more efficacious for improving blood flow

Betaine Anhydrous

Betaine is a hygroscopic osmolyte also known as trimethylglycine

• reduces homocysteine concentrations
• improves muscle oxygenation
• increases exercise training volume

L-Tyrosine

L-Tyrosine is an amino acid that is a precursor to neurotransmitters that can enhance attention

• Improve memory
• Increase focus
• Protects against stress factors caused by intesnse training

Caffeine Anhydrous

Caffeine is a xanthine molecule with pronounced biological effects

• Caffeine causes adrenaline release
• Adrenaline gives us the best of both worlds – increased calorie burn and increased fat burn.
• Increases pain tolerance, which is believed to be the primary mechanism by which it can improve endurance and athletic performance.

2 unique forms of caffeine which may extend the release curve of caffeine for a more sustained effect and a smoother experience.

Rauwolfia Vomitoria

An herb with a powerful profile of alkaloids.

• Alpha yohimbine works synergistically with caffeine
• Alpha-yohimbine is an alpha-adrenergic antagonist that may help boost mood.

Huperzia Serrata

Huperzine is an acetylcholinesterase inhibitor.

• Acetylcholine is a molecule which triggers muscle contraction.
• By inhibiting the enzyme (acetylcholinesterase) that breaks down acetylcholine, more acetylcholine is available to send those cellular signals.

FAQ

Q: What is the best way to use Epitome?

A: As a dietary supplement, take one scoop with 8-12 fl oz of water. New users may wish to begin with a half scoop to assess tolerance.

Q: Can I stack Epitome?

A: yes, for best results, stack with Essentials to jumpstart recovery and sustain workout performance.

References

Vitamin B6

1. Clayton, P. T. (2006). B 6-responsive disorders: a model of vitamin dependency. Journal of inherited metabolic disease, 29(2-3), 317-326.
2. Allgood, V. E., & Cidlowski, J. A. (1992). Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily. Journal of Biological Chemistry, 267(6), 3819-3824.

Vitamin B3

1. Mach, J., Midgley, A. W., Dank, S., Grant, R. S., & Bentley, D. J. (2010). The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+ (H). Nutrients, 2(3), 319-329.
2. Sauve, A. A. (2008). NAD+ and vitamin B3: from metabolism to therapies. Journal of Pharmacology and Experimental Therapeutics, 324(3), 883-893.
3. Kaplon, R. E., Gano, L. B., & Seals, D. R. (2014). Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. Journal of applied physiology, 116(2), 156-163.

Beta-Alanine

1. Miyaji, T., Sato, M., Maemura, H., Takahata, Y., & Morimatsu, F. (2012). Expression profiles of carnosine synthesis–related genes in mice after ingestion of carnosine or β-alanine. Journal of the International Society of Sports Nutrition, 9(1), 15.
2. Kern, B. D., & Robinson, T. L. (2011). Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players. The Journal of Strength & Conditioning Research, 25(7), 1804-1815.
3. Stout, J. R., Cramer, J. T., Zoeller, R. F., Torok, D., Costa, P., Hoffman, J. R., ... & O’kroy, J. (2007). Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino acids, 32(3), 381-386.

L-Citrulline

1. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. The Journal of Strength & Conditioning Research, 24(5), 1215-1222.
2. Wax, B., Kavazis, A. N., Weldon, K., & Sperlak, J. (2015). Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters. The Journal of Strength & Conditioning Research, 29(3), 786-792.
3. Ochiai, M., Hayashi, T., Morita, M., Ina, K., Maeda, M., Watanabe, F., & Morishita, K. (2012). Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. International journal of cardiology, 155(2), 257-261.
4. Glenn, J. M., Gray, M., Wethington, L. N., Stone, M. S., Stewart, R. W., & Moyen, N. E. (2017). Acute citrulline malate supplementation improves upper-and lower-body submaximal weightlifting exercise performance in resistance-trained females. European journal of nutrition, 56(2), 775-784.

Betaine Anhydrous

1. Schwab, U., Alfthan, G., Aro, A., & Uusitupa, M. (2011). Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects. European journal of clinical nutrition, 65(1), 70-76.
2. Trepanowski, J. F., Farney, T. M., Mccarthy, C. G., Schilling, B. K., Craig, S. A., & Bloomer, R. J. (2011). The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. The Journal of Strength & Conditioning Research, 25(12), 3461-3471.
3. Armstrong, L. E., Casa, D. J., Roti, M. W., Lee, E. C., Craig, S. A., Sutherland, J. W., ... & Maresh, C. M. (2008). Influence of betaine consumption on strenuous running and sprinting in a hot environment. The Journal of Strength & Conditioning Research, 22(3), 851-860.

Nitrosigine

1. Rogers, J. M., Gills, J., & Gray, M. (2020). Acute effects of Nitrosigine® and citrulline maleate on vasodilation. Journal of the International Society of Sports Nutrition, 17(1), 1-8.
2. Rogers, J., Gills, J., & Gray, M. Comparing the Acute Effects of Citrulline Malate and Nitrosigine Supplementation in Young Adults.

L-Tyrosine

1. Banderet, L. E., & Lieberman, H. R. (1989). Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain research bulletin, 22(4), 759-762.
2. Fernstrom, J. D., & Fernstrom, M. H. (2007). Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. The Journal of nutrition, 137(6), 1539S-1547S.
3. Lehnert, H., & Wurtman, R. J. (1993). Amino acid control of neurotransmitter synthesis and release: physiological and clinical implications. Psychotherapy and psychosomatics, 60(1), 18-32.
4. Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine.

Alpha-GPC

1. Ziegenfuss, T., Landis, J., & Hofheins, J. (2008). Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Journal of the International Society of Sports Nutrition, 5(S1), P15.
2. Khosrow Tayebati, S., Tomassoni, D., Ejike Nwankwo, I., Di Stefano, A., Sozio, P., Serafina Cerasa, L., & Amenta, F. (2013). Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 12(1), 94-103.
3. Gatti, G., Barzaghi, N., Acuto, G., Abbiati, G., Fossati, T., & Perucca, E. (1992). A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers. International journal of clinical pharmacology, therapy, and toxicology, 30(9), 331-335.

Caffeine Anhydrous

1. Norager, C. B., Jensen, M. B., Weimann, A., & Madsen, M. R. (2006). Metabolic effects of caffeine ingestion and physical work in 75‐year old citizens. A randomized, double‐blind, placebo‐controlled, cross‐over study. Clinical endocrinology, 65(2), 223-228.
2. Desbrow, B., Biddulph, C., Devlin, B., Grant, G. D., Anoopkumar-Dukie, S., & Leveritt, M. D. (2012). The effects of different doses of caffeine on endurance cycling time trial performance. Journal of sports sciences, 30(2), 115-120.
3. Mora-Rodríguez, R., Pallarés, J. G., López-Samanes, Á., Ortega, J. F., & Fernández-Elías, V. E. (2012). Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men. PLoS One, 7(4), e33807.
4. Paton, C. D., Lowe, T., & Irvine, A. (2010). Caffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclists. European journal of applied physiology, 110(6), 1243-1250.

N-Phenethyl Dimethylamine Citrate

1. Hedman, K., Leander, K., & Luning, B. (1969). STUDIES ON ORCHIDACEAE ALKALOIDS. 15. PHENETHYLAMINES FROM ERIA-JARENSIS AMES. ACTA CHEMICA SCANDINAVICA, 23(9), 3261.

Rauwolfia Vomitoria

1. Perry, B. D., & U'Prichard, D. C. (1981). [3H] Rauwolscine (α-yohimbine): a specific antagonist radioligand for brain α2-adrenergic receptors. European journal of pharmacology, 76(4), 461-464.
2. Rockhold, R. W., & Gross, F. (1981). Yohimbine diastereoisomers: Cardiovascular effects after central and peripheral application in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 315(3), 227-231.

Huperzia Serrata

1. Boudinot, E., Taysse, L., Daulon, S., Chatonnet, A., Champagnat, J., & Foutz, A. S. (2005). Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase. Pharmacology biochemistry and behavior, 80(1), 53-61.